Matasaku Shiobara, one of the three founders of “Sankyo Shoten,” which sold Dr. Jokichi Takamime's famous digestive, Taka-Diastase, in Japan

Strong friendship and passion to deliver good medicine—the founding of “Sankyo Shoten”

June 29, 2023
Our People & Culture
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Japanese scientist, researcher and entrepreneur, Dr. Jokichi Takamine, developed a digestive drug, “Taka-Diastase,” in the United States and “Sankyo Shoten” then founded to sell it in Japan. Sankyo Shoten is the predecessor of Sankyo Co., Ltd., where Dr. Takamine served as the first president.

A strong friendship leads to the import of Taka-Diastase

A central figure in Sankyo Shoten was Matasaku Shiobara, a merchant selling silk fabric to foreign trading houses in Yokohama from 1897. Mr. Shiobara wanted to expand his business and learned that his friend, Shotaro Nishimura, who was engaged in the export of green tea, was planning to visit the United States. While he was there, Mr. Shiobara asked him to explore potential opportunities in the United States that could be turned into businesses in Japan.

The following year, during his stay in the United States, Mr. Nishimura was invited to have a Japanese meal at the Japanese consulate. After already having eaten a lot of food, he was served sushi. Just as he was thinking, “I can’t eat any more,” Shingoro Nose, the consul in Chicago, introduced the digestive enzyme, Taka-Diastase, to Nishimura. Upon taking the drug, he was surprised by its efficacy and believed it would be useful for the Japanese, whose staple food was rice. Having the intuition that it could provide a new business opportunity for Mr. Shiobara, Mr. Nishimura visited Dr. Jokichi Takamine, who had invented Taka-Diastase, and asked him to grant Mr. Shiobara the right to sell it in Japan.

Dr. Takamine, who was already contemplating selling it in Japan, was so moved by Mr. Nishimura’s passion that he provided him with a free sample. After returning to Japan, Nishimura encouraged Mr. Shiobara to acquire its sales rights. On receiving the medicine from Mr. Nishimura, Mr. Shiobara soon began negotiations, expecting to quickly grow sales of the important medicine in Japan.

 

Sankyo Shoten Drug Divison opened in Nihonbashi district of Tokyo

Founding of “Sankyo Shoten”: Import and sales of adrenaline and other products leading to rapid growth

In December 1898, Mr. Shiobara and Dr. Takamine signed a consignment contract followed by the founding of an anonymous joint stock company “Sankyo Shoten” (Sankyo Store) in Yokohama by Mr. Shiobara, Mr. Nishimura, and their friend Mr. Genjiro Fukui. Since the company was founded by three people, the name “Sankyo” was selected, with the two characters that make it up meaning “three” and “cooperation”.

Sankyo Shoten’s first business was bottling imported Taka-Diastase and selling it to a pharmacy located at the central part of Tokyo. At that time, importing and selling medicines backed by academic research was an epoch-making event in Japan, where only the production and sales of easy-to-make galenical preparations were predominant—galenical preparations are a general term for medical agents using active ingredients extracted from crude drugs.

Owing to Mr. Shiobara’s steady efforts, the company proceeded as expected and began operations in Tokyo three years later. It had licensed resellers not only Tokyo and its suburb but also Kyoto, Osaka and its suburb, further expanding their sales channels.

In 1900, Mr. Shiobara learned that Dr. Takamine had succeeded in extracting adrenaline and asked him to entrust the sale of adrenaline in Japan exclusively to Sankyo Shoten. Two years later, when Dr. Takamine and his wife Caroline visited Japan, Mr. Shiobara greeted them in Kobe and negotiated personally with Dr. Takamine. Since Dr. Takamine highly appreciated Mr. Shiobara’s personality and record, they quickly concluded a contract. Subsequently, adrenaline was widely used in Japan as a medicine to stop bleeding and increase blood pressure.

As Sankyo Shoten was selected as the sole licensed reseller in Japan for Parke-Davis (now Pfizer), which sold adrenaline in the United States, the number of drugs sold by Sankyo Shoten increased and the company’s Yokohama store soon became too small to accommodate the growing product lines. A new store, “Sankyo Shoten Yakuhin-bu (drug division),” was opened in Nihonbashi district of Tokyo, which was close to the current Daiichi Sankyo’s headquarters.

Mr. Shiobara continued to be directly involved in the business, focusing his efforts on advertising activities. He personally wrote copy for product advertisements as well as simultaneously created and distributed a quarterly journal with advertisements for patient enrollment in clinical trials. Through these efforts, his company further won the trust of doctors and patients.

Going beyond the import and sale business to embark on a pharmaceutical manufacturing business

Later on, Mr. Shiobara visited the United States, attending a medical convention and visiting a Parke-Davis plant, where he strengthened the relationship with the company. Before returning to Japan, he also visited various European countries to broaden his knowledge, deciding to go beyond the import and sales business and begin a pharmaceutical manufacturing business. In 1905, he built a plant in the Nihonbashi district, approximately 10 minutes from the company’s Tokyo store. He embarked on the manufacture of one new medicine after another, such as “Glyconal,” a nutritional supplement, and “Lactostase,” a lactobacillus preparation, succeeding with all of them.

Through these myriad activities, the company accumulated experience as a pharmaceutical company, eventually changing its name from Sankyo Shoten to Sankyo Co., Ltd., in 1913. Many years later, Mr. Shiobara’s passion and enthusiasm to deliver good medicines to patients were passed down and inherited by the Daiichi Sankyo Group of companies.

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