Preventing Air and Water Pollution

As a pharmaceutical company handling various chemical substances, the Daiichi Sankyo Group considers proper management of chemical substances as an important initiative and issue. To prevent air and water pollution, the Group has established voluntary control standards that are stricter than legal requirements and properly monitors the emissions at plants and R&D centers in Group companies in Japan. Similarly, Group company plants outside Japan including Daiichi Sankyo Pharmaceutical (Beijing), Daiichi Sankyo Pharmaceutical (Shanghai), Daiichi Sankyo Europe (Germany), and Daiichi Sankyo Brasil Farmaceutica also regularly monitor their emissions to ensure compliance with the laws and regulations of each country and region.

Preventing Soil and Groundwater Contamination and Countermeasures against it

Plants and research centers make efforts to prevent soil and groundwater contamination. When the obliged investigation is required based on the Soil Contamination Countermeasures Act and related prefectural ordinance, we conduct the appropriate investigation according to the laws and regulations on discussion with the governmental offices.
Furthermore, we similarly also conduct investigations according to the laws and regulations even in the cases where mandatory regulations do not apply, such as the closing of offices and change of using purpose.
If contamination occurs, we report it to the related government offices and properly disclose information to members of the surrounding community, and take appropriate measures (such as prevention of diffusion and purification) according to the extent of contamination. The offices that have already taken measures, such as purification, continue to monitor and report the result of analysis to governmental offices and community members.

Progress of Measures for Soil Purification

Office Overview
Shinagawa R&D Center (Shinagawa-ku, Tokyo) We performed a soil investigation associated with the construction of new research facilities according to Tokyo municipal ordinance. As a result, contamination was found in a part of soil. Thus we performed purification work appropriately on discussion with the governmental offices.
The site of former Yasugawa plant (Yasu City, Shiga)
Considering requests from local government agencies and neighborhood councils, among others, we decided to remove an underground storage facility for contaminated soil that has been managed properly in accordance with administrative guidance. In removing the facility, we will comply with environmental laws and regulations and place utmost priority on the safety and security of the local community.

*Volatile Organic Compounds

Prevention of Noise, Vibration, and Offensive Odors

We conduct appropriate measures and continuous monitoring to comply with the laws and regulations related to noise, vibration, and offensive odor.

Appropriate Management and Emission and Transfer Control of Chemical Substances

We manage properly chemical substances that may adversely affect human health or the ecosystem based on the PRTR*2 system provided in the Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof. The amount of chemical substances handled that are subject to the PRTR system in fiscal 2019 increased to 1,798 metric tons from 2,301 metric tons in fiscal 2018 due to an increase in the amount of production. Emissions to air and water increased by 2 tons compared to fiscal 2018, which was a smaller increase than that of the amount of chemical substances handled. We will continue to control emissions into the environment based on proper chemical substance management.
There was no transport, import, export, or treatment of waste that was deemed hazardous nor was there any transport of waste that was shipped internationally as described in the terms of the Basel Convention Annex I, II, III, and VIII.

*2Pollutant Release and Transfer Register

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Storage and Usage of PCB Contaminants

Evaluation of the Environmental Impact of Pharmaceutical Products

The Daiichi Sankyo Group conducts the necessary environmental impact assessments for its pharmaceuticals based on the guidelines of relevant countries and implements measures as appropriate.
The Group realizes that one of the sustainability risks associated with its business activities is the possible negative impacts of pharmaceutical manufacturing and its by-products on the environment. There have been incidents in the past in which by-products of pharmaceutical manufacturing were detected in rivers and other natural environments. The Group is well aware that social concern is rising with regard to this issue as well as its potential environmental repercussions. The Group watches closely such social responses and the global trend toward promotion of initiatives for EPS*3 by the European Federation of Pharmaceutical Industries and Associations (EFPIA).
We believe that we need to continuously coordinate with governments, industry organizations, and research institutions to examine more appropriate risk evaluations and risk management.

*3EPS (Eco-Pharmaco-Stewardship): Voluntary initiatives to prevent environmental impacts throughout the lifecycle of pharmaceuticals and eco-friendly product management.

Environmental Impact Assessment of the Manufacturing Processes

As the changes in manufacturing processes for pharmaceutical products are regulated by pharmaceutical related laws and regulations, such changes require considerable time and effort. Accordingly, it is important to discuss and evaluate changes not only from the view of quality and cost, but also from a wide range of perspectives including impact on environment at the stage of research and development of manufacturing process.
When developing manufacturing processes for new products, the Daiichi Sankyo Group uses its own evaluation indicators*4 to determine the impact of these processes on the environment. This approach is based on the concept of eco-friendly green chemistry. Through this approach, we aim to create manufacturing processes that are considerate of the sustainability of the natural environment by developing new synthetic processes, preventing pollution, and reducing resource and energy consumption.
For manufacturing processes that produce waste, we discuss and evaluate methods through which the waste can be collected and reused as well as methods of treating this waste that are highly safe and have a low environmental impact.
The result of this research leads to a great reduction of the environmental impact of the final manufacturing process (industrialized manufacturing method) compared with the impact when this research had just begun.

*4Indicators established by scoring the items such as the safety or toxicity, operating condition, and waste volumes, etc., of solvents or reagents

Initiatives for Biodiversity Conservation

The Group’s Basic Environmental Management Policy and the Mid-term Environmental Management Policy stipulate that its business activities must consider biodiversity and ecosystem services. The Group has established the Basic Biodiversity Principles and Action Guidelines based on these policies. Moreover, when this was established, the Group surveyed its initiatives on biodiversity, the use of natural resources, and status of efforts to comply with the Cartagena Protocol both in and outside Japan. In addition, the Group assessed the relationship between its business activities and biodiversity and identified issues through an analysis of the Group’s risks and opportunities. (Please refer to the diagram “Map of corporate activities and biodiversity” below.)
The Daiichi Sankyo Group believes that biodiversity conservation and sustainable use of ecosystem services are essential in performing business. We promote the raising of awareness and understanding of employees, as well as the strengthening of environmental conservation activities in collaboration with business partners and private groups, to procure materials with less environmental burden, and to socially contribute towards biodiversity conservation.

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Ecological Footprint

We assess the ecological footprint (EF), an indicator of biodiversity, jointly with experts from the NGO, Global Footprint Network, to examine all environmental burdens in the business activities of Group companies in Japan. The assessed EF is used as a comprehensive indicator of environmental burdens, including those related to biodiversity, by checking and monitoring long-term changes in the relationship between the reduction of environmental burdens and biodiversity conservation (trade-off) in the Group.
This initiative has been recognized as an action for achieving the Aichi Target (20 targets) that was adopted at COP10 (the 10th Meeting of the Conference of the Parties to the Convention on Biological Diversity in Nagoya) and has been registered on the Nijyu-Maru Project as well. In addition, it was introduced as an example of monitoring biodiversity in the Guidelines for Private Sector Engagement in Biodiversity (Second Edition) issued by the Ministry of the Environment of Japan.

Initiatives for Biodiversity Conservation

Conservation for rare species of plants

To preserve the golden orchid (designated as critically endangered Type II in the Japanese Ministry of the Environment’s Red Data Book) and the silver orchid, we have prohibited entry into the forested area of the property at the Tatebayashi Biopharmaceuticals Center where the plant naturally grows (approximately 1,000 m2). The continued conservation effort has been resulted in an increase in the population of the species and expansion of breeding range.

Golden orchid

Silver orchid

Greening in harmony with the surrounding environment

The Kitamoto Office of Daiichi Sankyo Biotech Co., Ltd. engages in environmental conservation that takes into account the surrounding natural environment and ecosystem, and implements sound insulation and greening in harmony with the neighboring Kitamoto Nature Observation Park.
Recognized for its various diversity-friendly initiatives, the office was given the 7th Sainokuni Green Plan Award in 2015. The award is granted by Saitama Prefecture to facilities that have achieved excellent greening and sound maintenance.
The office continues to engage in environmental conservation through greening and other ecosystem protection measures.

Implementation of WET testing

With the purpose of assessing the impact of water discharged from operation sites, in fiscal 2019, we continued to conduct WET testing* at all plants and research facilities in Japan (eight operation sites). As a result, we confirmed that the discharged water has no serious impact on aquatic organisms in rivers, etc. In fiscal 2020, we plan to conduct WET testing at all of our plants and research facilities in Japan to promote appropriate wastewater management and improve the quality of discharged water.

Whole Effluent Toxicity Test. A testing method that utilizes the biological responses of fish, daphnia, and seaweed to determine the total toxicity of discharged water.

Extracting water for the WET test